In Redemption®, special abilities always target cards. You may NOT force your opponent to do something that affects a card that is immune to your character or that is protected from that effect. You may NOT do something yourself that affects a card that is immune to your character.
Example: Obedience of Noah ("Holder may choose the Evil Character his opponent uses to block his rescue attempt") played on Thomas could not affect Prince of this World, since the holder of Thomas is trying to affect Prince of this World, not the holder of Prince of this World.